Muscadet Sèvre-et-Maine is the best known of the Muscadet appellations of the Loire Valley's Pays Nantais district, on the central western coast of France. The title covers exclusively white wines from vineyards southeast and east of the city of Nantes, around the Sèvre Nantaise river and its tributary, La Maine, at the western end of the Loire region.

Muscadet Sèvre-et-Maine is made solely from Melon de Bourgogne, a grape variety brought to the western Loire from Burgundy, as the name suggests. The similarity between the name Muscadet and that of the Muscat variety is sometimes the cause of confusion. But a single taste of a crisp, dry Muscadet wine will confirm that it is definitely not made from Muscat, a notoriously aromatic (and often sweet) variety.